Skip to main content
WCS
Menu
Library
Library Catalog
eJournals & eBooks
WCS Research
Archives
Research Use
Finding Aids
Digital Collections
WCS History
WCS Research
Research Publications
Science Data
Services for WCS Researchers
Archives Shop
Bronx Zoo
Department of Tropical Research
Browse By Product
About Us
FAQs
Intern or Volunteer
Staff
Donate
Search WCS.org
Search
search
Popular Search Terms
WCS History
Library and Archives
Library and Archives Menu
Library
Archives
WCS Research
Archives Shop
About Us
Donate
en
fr
Title
Evaluation of an osmotic pump for fentanyl administration in cats as a model for nondomestic felids
Author(s)
Sykes, JM; Cox, S; Ramsay, EC
Published
2009
Publisher
American Journal of Veterinary Research
Abstract
Objective-To evaluate the reliability of an SC implanted osmotic pump (OP) for fentanyl administration in cats and to compare serum concentrations of fentanyl delivered via an OP and a transdermal patch (TP). Animals-8 spayed female cats. Procedures-In a crossover design, cats received fentanyl at 25 mu g/h via a TP or an OP All cats were anesthetized for the pump or patch placement (0 hours) and again when it was removed (96 hours). Venous blood samples were collected for measurement of serum fentanyl concentrations at 0, 6, 12, 24, 36, 48, 72, and 96 hours and at 24 and 48 hours after device removal. After a 3-week washout period, the experiment was repeated with each cat receiving the other treatment. Results-Mean serum fentanyl concentrations at 24, 36, 72, and 96 hours were greater when the OP was used than when the TP was used. Mean residence time and half-life were greater when the TP was used. Fentanyl concentration changed significantly faster in initial and elimination phases when the OP was used. Marked interindividual variation in serum fentanyl concentrations was evident with both administration methods. No adverse effects were evident with either method. Conclusions and Clinical Relevance-Use of the OP to administer fentanyl to cats resulted in a shorter initial lag phase to a therapeutic serum concentration, higher bioavailability, and faster elimination after removal, compared with use of a TP These advantages, in addition to the inability of cats to remove the OP may make OPs useful for fentanyl administration in nondomestic felids. (Am J Vet Res 2009,70:950-955)
Keywords
TRANSDERMALLY ADMINISTERED FENTANYL; PLASMA-CONCENTRATIONS; INTRAVENOUS FENTANYL; ANALGESIA; PHARMACOKINETICS; PATCHES; DOGS; OVARIOHYSTERECTOMY; DISPOSITION; ONYCHECTOMY
Access Full Text
A full-text copy of this article may be available. Please email the
WCS Library
to request.
Back
PUB10367