Title
Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles
Author(s)
Garner T.W.J., Garcia G., Carroll B., Fisher M.C.
Published
2009
Publisher
Diseases of Aquatic Organisms
Published Version DOI
https://doi.org/10.3354/dao02008
Abstract
Batrachochytrium dendrobatidis (Bd) is a global threat to amphibian biodiversity. Current calls for conservation through captive breeding require that efficient and reliable antifungal treatments be developed for target species. Here we confirm that the antifungal itraconazole is an effective treatment for infection in larval Alytes muletensis. Exceptionally low doses applied as few as 7 times were effective at clearing infection from tadpoles for up to 28 d after treatment. However, we cannot recommend itraconazole as a treatment for this species as depigmentation of tadpoles was observed. Further research is required to determine the putative hepatotoxicity of this treatment. © Inter-Research 2009.
Keywords
antifungal agent; itraconazole; pigment; amphibian; biodiversity; disease treatment; drug; frog; fungal disease; fungus; pigment; animal; animal disease; article; Chytridiomycetes; drug effect; frogs and toads; mycosis; physiology; Animals; Antifungal Agents; Anura; Chytridiomycota; Itraconazole; Mycoses; Pigments, Biological; Alytes muletensis; Amphibia; Batrachochytrium dendrobatidis

Access Full Text

A full-text copy of this article may be available. Please email the WCS Library to request.



Back

PUB11918