Title
Multiple Ebola Virus Transmission Events and Rapid Decline of Central African Wildlife
Author(s)
Leroy, E.M.; Rouquet, P.; Formenty, P.; Souquiere, S.; Kilbourne, A.; Froment, J.-M.; Bermejo, M.; Smit, S.; Karesh, W.; Swanepoel, R.; Zaki, S.R.; Rollin, P.E.
Published
2004
Publisher
Science
Abstract
Several human and animal Ebola outbreaks have occurred over the past 4 years in Gabon and the Republic of Congo. The human outbreaks consisted of multiple simultaneous epidemics caused by different viral strains, and each epidemic resulted from the handling of a distinct gorilla, chimpanzee, or duiker carcass. These animal populations declined markedly during human Ebola outbreaks, apparently as a result of Ebola infection. Recovered carcasses were infected by a variety of Ebola strains, suggesting that Ebola outbreaks in great apes result from multiple virus introductions from the natural host. Surveillance of animal mortality may help to predict and prevent human Ebola outbreaks.
Keywords
Biodiversity; Diseases; Epidemiology; Forestry; Wildlife; Viruses; disease transmission; mortality; primate; virus; article; carcass; Congo; Ebola virus; epidemic; epidemiological data; Gabon; gorilla; host; human; mortality; nonhuman; prediction; priority journal; viral genetics; virus strain; virus transmission; wildlife conservation; Africa, Central; Animals; Animals, Wild; Ape Diseases; Base Sequence; Disease Outbreaks; Disease Reservoirs; Ebolavirus; Gabon; Genes, Viral; Gorilla gorilla; Hemorrhagic Fever, Ebola; Humans; Molecular Sequence Data; Pan troglodytes; Population Density; Population Surveillance; Ruminants; Viral Envelope Proteins; Animalia; Ebola virus; Pan troglodytes; Primates; RNA viruses; SEQUENCE-ANALYSIS; OUTBREAK; REEMERGENCE

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PUB12452