Title
Feline immunodeficiency virus (FIV) in wild Pallas' cats
Author(s)
Brown, Meredith A.;Munkhtsog, Bariushaa;Troyer, Jennifer L.;Ross, Steve;Sellers, Rani;Fine, Amanda E.;Swanson, William F.;Roelke, Melody E.;O'Brien, Stephen J.
Published
2010
Publisher
Veterinary Immunology and Immunopathology
Abstract
Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host.
Keywords
FIV;Pallas' cat;Evolution;Histopathology;Felidae

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PUB13470